Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis
Identifieur interne : 000843 ( Main/Exploration ); précédent : 000842; suivant : 000844Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis
Auteurs : Clark A. Santee [États-Unis] ; Nabeetha A. Nagalingam [États-Unis] ; Ali A. Faruqi [États-Unis] ; Gregory P. Demuri [États-Unis] ; James E. Gern [États-Unis] ; Ellen R. Wald [États-Unis] ; Susan V. Lynch [États-Unis]Source :
- Microbiome [ 2049-2618 ] ; 2016.
Abstract
Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI.
Healthy children (
These preliminary data suggest that previous history of acute sinusitis influences the composition of the NP microbiota, characterized by a depletion in relative abundance of specific taxa. Diminished diversity was associated with more frequent URIs.
The online version of this article (doi:10.1186/s40168-016-0179-9) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s40168-016-0179-9
PubMed: 27364497
PubMed Central: 4929776
Affiliations:
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Santee</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Nagalingam, Nabeetha A" sort="Nagalingam, Nabeetha A" uniqKey="Nagalingam N" first="Nabeetha A." last="Nagalingam">Nabeetha A. Nagalingam</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco</wicri:cityArea></affiliation><affiliation><nlm:aff id="Aff3">Present address: Janssen Prevention Center, 2 Royal College Street, London, NW1 0TU UK</nlm:aff><wicri:noCountry code="subfield">NW1 0TU UK</wicri:noCountry></affiliation></author><author><name sortKey="Faruqi, Ali A" sort="Faruqi, Ali A" uniqKey="Faruqi A" first="Ali A." last="Faruqi">Ali A. Faruqi</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Demuri, Gregory P" sort="Demuri, Gregory P" uniqKey="Demuri G" first="Gregory P." last="Demuri">Gregory P. Demuri</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Gern, James E" sort="Gern, James E" uniqKey="Gern J" first="James E." last="Gern">James E. Gern</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Wald, Ellen R" sort="Wald, Ellen R" uniqKey="Wald E" first="Ellen R." last="Wald">Ellen R. Wald</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison</wicri:cityArea></affiliation></author><author><name sortKey="Lynch, Susan V" sort="Lynch, Susan V" uniqKey="Lynch S" first="Susan V." last="Lynch">Susan V. Lynch</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author></analytic><series><title level="j">Microbiome</title><idno type="eISSN">2049-2618</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI.</p></sec><sec><title>Results</title><p>Healthy children (<italic>n</italic> = 47) aged 49–84 months from a prospective cohort study based in Wisconsin, USA, were examined. Demographic and clinical data and NP swab samples were obtained from participants upon entry to the study. All NP samples were profiled for bacterial microbiota using a phylogenetic microarray, and these data were related to demographic characteristics and upper respiratory health outcomes. The composition of the NP bacterial community of children was significantly related prior to the history of acute sinusitis (<italic>R</italic><sup>2</sup> = 0.070, <italic>P</italic> < 0.009). History of acute sinusitis was associated with significant depletion in relative abundance of taxa including <italic>Faecalibacterium prausnitzii</italic> and <italic>Akkermansia</italic> spp. and enrichment of <italic>Moraxella nonliquefaciens</italic>. Enrichment of <italic>M. nonliquefaciens</italic> was also a characteristic of baseline NP samples of children who subsequently developed acute sinusitis over the 1-year study period. Time to develop URI was significantly positively correlated with NP diversity, and children who experienced more frequent URIs exhibited significantly diminished NP microbiota diversity (<italic>P</italic> ≤ 0.05).</p></sec><sec><title>Conclusions</title><p>These preliminary data suggest that previous history of acute sinusitis influences the composition of the NP microbiota, characterized by a depletion in relative abundance of specific taxa. Diminished diversity was associated with more frequent URIs.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s40168-016-0179-9) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ball, Tm" uniqKey="Ball T">TM Ball</name></author><author><name sortKey="Holberg, Cj" uniqKey="Holberg C">CJ Holberg</name></author><author><name sortKey="Aldous, Mb" uniqKey="Aldous M">MB Aldous</name></author><author><name sortKey="Martinez, Fd" uniqKey="Martinez F">FD Martinez</name></author><author><name sortKey="Wright, Al" uniqKey="Wright A">AL Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wald, Er" uniqKey="Wald E">ER Wald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kloepfer, Km" uniqKey="Kloepfer K">KM Kloepfer</name></author><author><name sortKey="Lee, Wm" uniqKey="Lee W">WM Lee</name></author><author><name sortKey="Pappas, Te" uniqKey="Pappas T">TE Pappas</name></author><author><name sortKey="Kang, Tj" uniqKey="Kang T">TJ Kang</name></author><author><name sortKey="Vrtis, Rf" uniqKey="Vrtis R">RF Vrtis</name></author><author><name sortKey="Evans, Md" uniqKey="Evans M">MD Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Backhed, F" uniqKey="Backhed F">F Backhed</name></author><author><name sortKey="Roswall, J" uniqKey="Roswall J">J Roswall</name></author><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y Peng</name></author><author><name sortKey="Feng, Q" uniqKey="Feng Q">Q Feng</name></author><author><name sortKey="Jia, H" uniqKey="Jia H">H Jia</name></author><author><name sortKey="Kovatcheva Datchary, P" uniqKey="Kovatcheva Datchary P">P Kovatcheva-Datchary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stearns, Jc" uniqKey="Stearns J">JC Stearns</name></author><author><name sortKey="Davidson, Cj" uniqKey="Davidson C">CJ Davidson</name></author><author><name sortKey="Mckeon, S" uniqKey="Mckeon S">S McKeon</name></author><author><name sortKey="Whelan, Fj" uniqKey="Whelan F">FJ Whelan</name></author><author><name sortKey="Fontes, Me" uniqKey="Fontes M">ME Fontes</name></author><author><name sortKey="Schryvers, Ab" uniqKey="Schryvers A">AB Schryvers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teo Shu, M" uniqKey="Teo Shu M">M Teo Shu</name></author><author><name sortKey="Mok, D" uniqKey="Mok D">D Mok</name></author><author><name sortKey="Pham, K" uniqKey="Pham K">K Pham</name></author><author><name sortKey="Kusel, M" uniqKey="Kusel M">M Kusel</name></author><author><name sortKey="Serralha, M" uniqKey="Serralha M">M Serralha</name></author><author><name sortKey="Troy, N" uniqKey="Troy N">N Troy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biesbroek, G" uniqKey="Biesbroek G">G Biesbroek</name></author><author><name sortKey="Tsivtsivadze, E" uniqKey="Tsivtsivadze E">E Tsivtsivadze</name></author><author><name sortKey="Sanders, Ea" uniqKey="Sanders E">EA Sanders</name></author><author><name sortKey="Montijn, R" uniqKey="Montijn R">R Montijn</name></author><author><name sortKey="Veenhoven, Rh" uniqKey="Veenhoven R">RH Veenhoven</name></author><author><name sortKey="Keijser, Bj" uniqKey="Keijser B">BJ Keijser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kane, M" uniqKey="Kane M">M Kane</name></author><author><name sortKey="Case, Lk" uniqKey="Case L">LK Case</name></author><author><name sortKey="Kopaskie, K" uniqKey="Kopaskie K">K Kopaskie</name></author><author><name sortKey="Kozlova, A" uniqKey="Kozlova A">A Kozlova</name></author><author><name sortKey="Macdearmid, C" uniqKey="Macdearmid C">C MacDearmid</name></author><author><name sortKey="Chervonsky, Av" uniqKey="Chervonsky A">AV Chervonsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Aa" uniqKey="Bosch A">AA Bosch</name></author><author><name sortKey="Biesbroek, G" uniqKey="Biesbroek G">G Biesbroek</name></author><author><name sortKey="Trzcinski, K" uniqKey="Trzcinski K">K Trzcinski</name></author><author><name sortKey="Sanders, Ea" uniqKey="Sanders E">EA Sanders</name></author><author><name sortKey="Bogaert, D" uniqKey="Bogaert D">D Bogaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lynch, Sv" uniqKey="Lynch S">SV Lynch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Jh" uniqKey="Wang J">JH Wang</name></author><author><name sortKey="Kwon, Hj" uniqKey="Kwon H">HJ Kwon</name></author><author><name sortKey="Jang, Yj" uniqKey="Jang Y">YJ Jang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verkaik, Nj" uniqKey="Verkaik N">NJ Verkaik</name></author><author><name sortKey="Nguyen, Dt" uniqKey="Nguyen D">DT Nguyen</name></author><author><name sortKey="De Vogel, Cp" uniqKey="De Vogel C">CP de Vogel</name></author><author><name sortKey="Moll, Ha" uniqKey="Moll H">HA Moll</name></author><author><name sortKey="Verbrugh, Ha" uniqKey="Verbrugh H">HA Verbrugh</name></author><author><name sortKey="Jaddoe, Vw" uniqKey="Jaddoe V">VW Jaddoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eveillard, M" uniqKey="Eveillard M">M Eveillard</name></author><author><name sortKey="Soltner, C" uniqKey="Soltner C">C Soltner</name></author><author><name sortKey="Kempf, M" uniqKey="Kempf M">M Kempf</name></author><author><name sortKey="Saint Andre, Jp" uniqKey="Saint Andre J">JP Saint-Andre</name></author><author><name sortKey="Lemarie, C" uniqKey="Lemarie C">C Lemarie</name></author><author><name sortKey="Randrianarivelo, C" uniqKey="Randrianarivelo C">C Randrianarivelo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernandez Pando, R" uniqKey="Hernandez Pando R">R Hernandez-Pando</name></author><author><name sortKey="Marquina Castillo, B" uniqKey="Marquina Castillo B">B Marquina-Castillo</name></author><author><name sortKey="Barrios Payan, J" uniqKey="Barrios Payan J">J Barrios-Payan</name></author><author><name sortKey="Mata Espinosa, D" uniqKey="Mata Espinosa D">D Mata-Espinosa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verduin, Cm" uniqKey="Verduin C">CM Verduin</name></author><author><name sortKey="Kools Sijmons, M" uniqKey="Kools Sijmons M">M Kools-Sijmons</name></author><author><name sortKey="Van Der Plas, J" uniqKey="Van Der Plas J">J van der Plas</name></author><author><name sortKey="Vlooswijk, J" uniqKey="Vlooswijk J">J Vlooswijk</name></author><author><name sortKey="Tromp, M" uniqKey="Tromp M">M Tromp</name></author><author><name sortKey="Van Dijk, H" uniqKey="Van Dijk H">H van Dijk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Vries, Sp" uniqKey="De Vries S">SP de Vries</name></author><author><name sortKey="Bootsma, Hj" uniqKey="Bootsma H">HJ Bootsma</name></author><author><name sortKey="Hays, Jp" uniqKey="Hays J">JP Hays</name></author><author><name sortKey="Hermans, Pw" uniqKey="Hermans P">PW Hermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abreu, Na" uniqKey="Abreu N">NA Abreu</name></author><author><name sortKey="Nagalingam, Na" uniqKey="Nagalingam N">NA Nagalingam</name></author><author><name sortKey="Song, Y" uniqKey="Song Y">Y Song</name></author><author><name sortKey="Roediger, Fc" uniqKey="Roediger F">FC Roediger</name></author><author><name sortKey="Pletcher, Sd" uniqKey="Pletcher S">SD Pletcher</name></author><author><name sortKey="Goldberg, An" uniqKey="Goldberg A">AN Goldberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Yc" uniqKey="Liu Y">YC Liu</name></author><author><name sortKey="Post, Jc" uniqKey="Post J">JC Post</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bogaert, D" uniqKey="Bogaert D">D Bogaert</name></author><author><name sortKey="Keijser, B" uniqKey="Keijser B">B Keijser</name></author><author><name sortKey="Huse, S" uniqKey="Huse S">S Huse</name></author><author><name sortKey="Rossen, J" uniqKey="Rossen J">J Rossen</name></author><author><name sortKey="Veenhoven, R" uniqKey="Veenhoven R">R Veenhoven</name></author><author><name sortKey="Van Gils, E" uniqKey="Van Gils E">E van Gils</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakwinska, O" uniqKey="Sakwinska O">O Sakwinska</name></author><author><name sortKey="Schmid, Vb" uniqKey="Schmid V">VB Schmid</name></author><author><name sortKey="Berger, B" uniqKey="Berger B">B Berger</name></author><author><name sortKey="Bruttin, A" uniqKey="Bruttin A">A Bruttin</name></author><author><name sortKey="Keitel, K" uniqKey="Keitel K">K Keitel</name></author><author><name sortKey="Lepage, M" uniqKey="Lepage M">M Lepage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derrien, M" uniqKey="Derrien M">M Derrien</name></author><author><name sortKey="Van Baarlen, P" uniqKey="Van Baarlen P">P Van Baarlen</name></author><author><name sortKey="Hooiveld, G" uniqKey="Hooiveld G">G Hooiveld</name></author><author><name sortKey="Norin, E" uniqKey="Norin E">E Norin</name></author><author><name sortKey="Muller, M" uniqKey="Muller M">M Müller</name></author><author><name sortKey="De Vos, Wm" uniqKey="De Vos W">WM de Vos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derrien, M" uniqKey="Derrien M">M Derrien</name></author><author><name sortKey="Vaughan, Ee" uniqKey="Vaughan E">EE Vaughan</name></author><author><name sortKey="Plugge, Cm" uniqKey="Plugge C">CM Plugge</name></author><author><name sortKey="De Vos, Wm" uniqKey="De Vos W">WM de Vos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Everard, A" uniqKey="Everard A">A Everard</name></author><author><name sortKey="Belzer, C" uniqKey="Belzer C">C Belzer</name></author><author><name sortKey="Geurts, L" uniqKey="Geurts L">L Geurts</name></author><author><name sortKey="Ouwerkerk, Jp" uniqKey="Ouwerkerk J">JP Ouwerkerk</name></author><author><name sortKey="Druart, C" uniqKey="Druart C">C Druart</name></author><author><name sortKey="Bindels, Lb" uniqKey="Bindels L">LB Bindels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Gutierrez, Rc" uniqKey="De Gutierrez R">RC de Gutierrez</name></author><author><name sortKey="Santos, V" uniqKey="Santos V">V Santos</name></author><author><name sortKey="Nader Macias, Me" uniqKey="Nader Macias M">ME Nader-Macías</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paynter, S" uniqKey="Paynter S">S Paynter</name></author><author><name sortKey="Ware, Rs" uniqKey="Ware R">RS Ware</name></author><author><name sortKey="Sly, Pd" uniqKey="Sly P">PD Sly</name></author><author><name sortKey="Williams, G" uniqKey="Williams G">G Williams</name></author><author><name sortKey="Weinstein, P" uniqKey="Weinstein P">P Weinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dethlefsen, L" uniqKey="Dethlefsen L">L Dethlefsen</name></author><author><name sortKey="Relman, Da" uniqKey="Relman D">DA Relman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dethlefsen, L" uniqKey="Dethlefsen L">L Dethlefsen</name></author><author><name sortKey="Huse, S" uniqKey="Huse S">S Huse</name></author><author><name sortKey="Sogin, Ml" uniqKey="Sogin M">ML Sogin</name></author><author><name sortKey="Relman, Da" uniqKey="Relman D">DA Relman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saulnier, Dm" uniqKey="Saulnier D">DM Saulnier</name></author><author><name sortKey="Riehle, K" uniqKey="Riehle K">K Riehle</name></author><author><name sortKey="Mistretta, Ta" uniqKey="Mistretta T">TA Mistretta</name></author><author><name sortKey="Diaz, Ma" uniqKey="Diaz M">MA Diaz</name></author><author><name sortKey="Mandal, D" uniqKey="Mandal D">D Mandal</name></author><author><name sortKey="Raza, S" uniqKey="Raza S">S Raza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujimura, Ke" uniqKey="Fujimura K">KE Fujimura</name></author><author><name sortKey="Rauch, M" uniqKey="Rauch M">M Rauch</name></author><author><name sortKey="Matsui, E" uniqKey="Matsui E">E Matsui</name></author><author><name sortKey="Iwai, S" uniqKey="Iwai S">S Iwai</name></author><author><name sortKey="Calatroni, A" uniqKey="Calatroni A">A Calatroni</name></author><author><name sortKey="Lynn, H" uniqKey="Lynn H">H Lynn</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wald, Er" uniqKey="Wald E">ER Wald</name></author><author><name sortKey="Applegate, Ke" uniqKey="Applegate K">KE Applegate</name></author><author><name sortKey="Bordley, C" uniqKey="Bordley C">C Bordley</name></author><author><name sortKey="Darrow, Dh" uniqKey="Darrow D">DH Darrow</name></author><author><name sortKey="Glode, Mp" uniqKey="Glode M">MP Glode</name></author><author><name sortKey="Marcy, Sm" uniqKey="Marcy S">SM Marcy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hazen, Tc" uniqKey="Hazen T">TC Hazen</name></author><author><name sortKey="Dubinsky, Ea" uniqKey="Dubinsky E">EA Dubinsky</name></author><author><name sortKey="Desantis, Tz" uniqKey="Desantis T">TZ DeSantis</name></author><author><name sortKey="Andersen, Gl" uniqKey="Andersen G">GL Andersen</name></author><author><name sortKey="Piceno, Ym" uniqKey="Piceno Y">YM Piceno</name></author><author><name sortKey="Singh, N" uniqKey="Singh N">N Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, Mj" uniqKey="Cox M">MJ Cox</name></author><author><name sortKey="Huang, Yj" uniqKey="Huang Y">YJ Huang</name></author><author><name sortKey="Fujimura, Ke" uniqKey="Fujimura K">KE Fujimura</name></author><author><name sortKey="Liu, Jt" uniqKey="Liu J">JT Liu</name></author><author><name sortKey="Mckean, M" uniqKey="Mckean M">M McKean</name></author><author><name sortKey="Boushey, Ha" uniqKey="Boushey H">HA Boushey</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lee, W M" uniqKey="Lee W">W-M Lee</name></author><author><name sortKey="Grindle, K" uniqKey="Grindle K">K Grindle</name></author><author><name sortKey="Pappas, T" uniqKey="Pappas T">T Pappas</name></author><author><name sortKey="Marshall, Dj" uniqKey="Marshall D">DJ Marshall</name></author><author><name sortKey="Moser, Mj" uniqKey="Moser M">MJ Moser</name></author><author><name sortKey="Beaty, El" uniqKey="Beaty E">EL Beaty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bochkov, Ya" uniqKey="Bochkov Y">YA Bochkov</name></author><author><name sortKey="Grindle, K" uniqKey="Grindle K">K Grindle</name></author><author><name sortKey="Vang, F" uniqKey="Vang F">F Vang</name></author><author><name sortKey="Evans, Md" uniqKey="Evans M">MD Evans</name></author><author><name sortKey="Gern, Je" uniqKey="Gern J">JE Gern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author><author><name sortKey="Lin, S" uniqKey="Lin S">S Lin</name></author><author><name sortKey="Kelen, Gd" uniqKey="Kelen G">GD Kelen</name></author><author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name></author><author><name sortKey="Dick, Jd" uniqKey="Dick J">JD Dick</name></author><author><name sortKey="Gaydos, Ca" uniqKey="Gaydos C">CA Gaydos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caporaso, Jg" uniqKey="Caporaso J">JG Caporaso</name></author><author><name sortKey="Kuczynski, J" uniqKey="Kuczynski J">J Kuczynski</name></author><author><name sortKey="Stombaugh, J" uniqKey="Stombaugh J">J Stombaugh</name></author><author><name sortKey="Bittinger, K" uniqKey="Bittinger K">K Bittinger</name></author><author><name sortKey="Bushman, Fd" uniqKey="Bushman F">FD Bushman</name></author><author><name sortKey="Costello, Ek" uniqKey="Costello E">EK Costello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faith, Dp" uniqKey="Faith D">DP Faith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilbe, J" uniqKey="Hilbe J">J Hilbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujimura, Ke" uniqKey="Fujimura K">KE Fujimura</name></author><author><name sortKey="Demoor, T" uniqKey="Demoor T">T Demoor</name></author><author><name sortKey="Rauch, M" uniqKey="Rauch M">M Rauch</name></author><author><name sortKey="Faruqi, A" uniqKey="Faruqi A">A Faruqi</name></author><author><name sortKey="Jang, S" uniqKey="Jang S">S Jang</name></author><author><name sortKey="Johnson, Cc" uniqKey="Johnson C">CC Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Letunic, I" uniqKey="Letunic I">I Letunic</name></author><author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Santee, Clark A" sort="Santee, Clark A" uniqKey="Santee C" first="Clark A." last="Santee">Clark A. Santee</name></region><name sortKey="Demuri, Gregory P" sort="Demuri, Gregory P" uniqKey="Demuri G" first="Gregory P." last="Demuri">Gregory P. Demuri</name><name sortKey="Faruqi, Ali A" sort="Faruqi, Ali A" uniqKey="Faruqi A" first="Ali A." last="Faruqi">Ali A. Faruqi</name><name sortKey="Gern, James E" sort="Gern, James E" uniqKey="Gern J" first="James E." last="Gern">James E. Gern</name><name sortKey="Lynch, Susan V" sort="Lynch, Susan V" uniqKey="Lynch S" first="Susan V." last="Lynch">Susan V. Lynch</name><name sortKey="Nagalingam, Nabeetha A" sort="Nagalingam, Nabeetha A" uniqKey="Nagalingam N" first="Nabeetha A." last="Nagalingam">Nabeetha A. Nagalingam</name><name sortKey="Wald, Ellen R" sort="Wald, Ellen R" uniqKey="Wald E" first="Ellen R." last="Wald">Ellen R. Wald</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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